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Title   장골에 발생한 골육종 환자에서 수술전 Cisplatin 동맥내 주입과 Adriamycin 계속 정주에 의한 항암 약물 치료 효과 ( The Efficacy of Pre - operative Chamotherapy with Intra-arterial Cisplatin and Intravenous Adriamycin for High Grade Osteosarcoma )
Publicationinfo   1999 Jan; 031(01): 134-144.
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Abstract   Purpose: Osteosarcoma is one of the most common juvenile malignant tumors in Korea. Combined modality treatment [pre-operative chemotherapy + surgery (limb salvage or amputation) + adjuvant chemotherapy] had improved the overall survival and quality of life. To improve the local control rate, we introduced pre-operative chemotherapy combined with intra-arterial (IA) cisplatin and continuous intravenous infusion (CI) of adriamycin. We evaluated the efficacy and feasibility, such as limb salvage rate, recurrence pattem and the survival impact, based on the histologic response of pre-operative chemotherapy. Materials and Methods: Fourty-one patients with histologicaUy-proven high grade osteosarcoma of the extremities were enrolled from January 1990 to June 1996. Pre-operative chemotherapy, cisplatin 120 mg/m IA and adriamycin 75 mg/m/72hrs CI, was administered for 3 cycles with 3 week interval, followed by surgery. Post-operative chemotherapy was applied by the tumor necrosis rate. If the tumor necrosis of the specimen was more than 90%, the same regimen af the preoperative one was administered
저 자   라선영(Sun Young Rha),공수정(Soo Jung Gong),정희철(Hee Cheol Chung),심광용(Kwang Yong Shim),안중배(Joong Bae Ahn),유내춘(Nae Choon Yoo),정현철(Hyn Cheol Chung),김주항(Joo Hang Kim),노재경(Hae Kyung Roh),민진식(Jin Sik Min),김병수(Byung Soo Kim),신규호(Kyu Ho Shin),야우익(Woo Ick Yang),이종인(Chon